7F6J

Crystal structure of the PDZD8 coiled-coil domain - Rab7 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ras-related protein Rab-7a	polymer	200	22649.8	2	UniProt (P51149) Pfam (PF00071) In PDB	Homo sapiens (Human)
2	C	PDZ domain-containing protein 8	polymer	133	15086.1	1	UniProt (Q8NEN9) In PDB	Homo sapiens (Human)	Sarcoma antigen NY-SAR-84/NY-SAR-104
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
5		water	water		18.0	154	Chemie (HOH)

Sequence modifications

A, B: 2 - 195 (UniProt: P51149)

PDB	External Database	Details
Gly -4	-	expression tag
Ser -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Leu 67	Gln 67	engineered mutation

C: 994 - 1123 (UniProt: Q8NEN9)

PDB	External Database	Details
Ser 991	-	expression tag
Ala 992	-	expression tag
Met 993	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	60385.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1095.0
All*	Total formula weight	61480.5

*Water molecules are not included.