7F3Z
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71909.1 | 2 | UniProt (C3S7P8) Pfam (PF00186) Pfam (PF00303) UniProt (by SIFTS) (P13922) | Plasmodium falciparum | |
| 2 | C, G (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, H (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
| 4 | E, I (A, B) | TRIMETHOPRIM | non-polymer | 290.3 | 2 | Chemie (TOP) | |||
| 5 | F, J (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143818.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2872.0 | |
| All* | Total formula weight | 146690.2 |
