7F3Y
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71828.0 | 2 | UniProt (A7UD81) Pfam (PF00186) Pfam (PF00303) UniProt (by SIFTS) (P13922) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | C, H (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, F, I (A, B) | METHOTREXATE | non-polymer | 454.4 | 3 | Chemie (MTX) | |||
| 4 | E, J (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
| 5 | G, K (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 546 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143656.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3654.7 | |
| All* | Total formula weight | 147310.7 |
