7F3T

Cryo-EM structure of human TMEM120A in the CoASH-bound state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transmembrane protein 120A	polymer	375	44843.6	2	UniProt (Q9BXJ8) Pfam (PF07851) In PDB	Homo sapiens (Human)	Ion channel TACAN,Transmembrane protein induced by tumor necrosis factor alpha
2	A, B	COENZYME A	non-polymer		767.5	2	Chemie (COA)

Sequence modifications

A, B: 2 - 343 (UniProt: Q9BXJ8)

PDB	External Database	Details
Met -31	-	expression tag
Asp -30	-	expression tag
Tyr -29	-	expression tag
Lys -28	-	expression tag
Asp -27	-	expression tag
Asp -26	-	expression tag
Asp -25	-	expression tag
Asp -24	-	expression tag
Lys -23	-	expression tag
Trp -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
Pro -19	-	expression tag
Gln -18	-	expression tag
Phe -17	-	expression tag
Glu -16	-	expression tag
Lys -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Trp -6	-	expression tag
Ser -5	-	expression tag
His -4	-	expression tag
Pro -3	-	expression tag
Gln -2	-	expression tag
Phe -1	-	expression tag
Glu 0	-	expression tag
Lys 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	89687.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1535.1
All*	Total formula weight	91222.2

*Water molecules are not included.