7F3B
cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 165 | 18848.2 | 1 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli (strain K12) | |
2 | A | 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine | non-polymer | 307.3 | 1 | Chemie (D4C) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
His 160 | - | expression tag |
His 161 | - | expression tag |
His 162 | - | expression tag |
His 163 | - | expression tag |
His 164 | - | expression tag |
His 165 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18848.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 491.5 | |
All* | Total formula weight | 19339.7 |