7F2O
Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | G subunit q (Gi1-Gq chimeric) | polymer | 361 | 41724.4 | 1 | Homo sapiens | ||
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41055.9 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Rat) | Transducin beta chain 1 |
3 | D | ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG | polymer | 9 | 1062.2 | 1 | UniProt (by SIFTS) (P01042) In PDB | Homo sapiens | |
4 | R | B2 bradykinin receptor | polymer | 595 | 67152.9 | 1 | UniProt (P30411) Pfam (PF00001) In PDB | Homo sapiens (Human) | B2R,BK-2 receptor |
5 | S | single Fab chain (svFv16) | polymer | 248 | 26392.4 | 1 | synthetic construct | ||
6 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
R: 40 - 370 (UniProt: P30411)
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala -66 | - | expression tag |
Asp -65 | - | expression tag |
Leu -64 | - | expression tag |
Glu -63 | - | expression tag |
Asp -62 | - | expression tag |
Asn -61 | - | expression tag |
Trp -60 | - | expression tag |
Glu -59 | - | expression tag |
Thr -58 | - | expression tag |
Leu -57 | - | expression tag |
Asn -56 | - | expression tag |
Asp -55 | - | expression tag |
Asn -54 | - | expression tag |
Leu -53 | - | expression tag |
Lys -52 | - | expression tag |
Val -51 | - | expression tag |
Ile -50 | - | expression tag |
Glu -49 | - | expression tag |
Lys -48 | - | expression tag |
Ala -47 | - | expression tag |
Asp -46 | - | expression tag |
Asn -45 | - | expression tag |
Ala -44 | - | expression tag |
Ala -43 | - | expression tag |
Gln -42 | - | expression tag |
Val -41 | - | expression tag |
Lys -40 | - | expression tag |
Asp -39 | - | expression tag |
Ala -38 | - | expression tag |
Leu -37 | - | expression tag |
Thr -36 | - | expression tag |
Lys -35 | - | expression tag |
Met -34 | - | expression tag |
Arg -33 | - | expression tag |
Ala -32 | - | expression tag |
Ala -31 | - | expression tag |
Ala -30 | - | expression tag |
Leu -29 | - | expression tag |
Asp -28 | - | expression tag |
Ala -27 | - | expression tag |
Gln -26 | - | expression tag |
Lys -25 | - | expression tag |
Ala -24 | - | expression tag |
Thr -23 | - | expression tag |
Pro -22 | - | expression tag |
Pro -21 | - | expression tag |
Lys -20 | - | expression tag |
Leu -19 | - | expression tag |
Glu -18 | - | expression tag |
Asp -17 | - | expression tag |
Lys -16 | - | expression tag |
Ser -15 | - | expression tag |
Pro -14 | - | expression tag |
Asp -13 | - | expression tag |
Ser -12 | - | expression tag |
Pro -11 | - | expression tag |
Glu -10 | - | expression tag |
Met -9 | - | expression tag |
Lys -8 | - | expression tag |
Asp -7 | - | expression tag |
Phe -6 | - | expression tag |
Arg -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Phe -2 | - | expression tag |
Asp -1 | - | expression tag |
Ile 0 | - | expression tag |
Leu 1 | - | expression tag |
Val 2 | - | expression tag |
Gly 3 | - | expression tag |
Gln 4 | - | expression tag |
Ile 5 | - | expression tag |
Asp 6 | - | expression tag |
Asp 7 | - | expression tag |
Ala 8 | - | expression tag |
Leu 9 | - | expression tag |
Lys 10 | - | expression tag |
Leu 11 | - | expression tag |
Ala 12 | - | expression tag |
Asn 13 | - | expression tag |
Glu 14 | - | expression tag |
Gly 15 | - | expression tag |
Lys 16 | - | expression tag |
Val 17 | - | expression tag |
Lys 18 | - | expression tag |
Glu 19 | - | expression tag |
Ala 20 | - | expression tag |
Gln 21 | - | expression tag |
Ala 22 | - | expression tag |
Ala 23 | - | expression tag |
Ala 24 | - | expression tag |
Glu 25 | - | expression tag |
Gln 26 | - | expression tag |
Leu 27 | - | expression tag |
Lys 28 | - | expression tag |
Thr 29 | - | expression tag |
Thr 30 | - | expression tag |
Arg 31 | - | expression tag |
Asn 32 | - | expression tag |
Ala 33 | - | expression tag |
Tyr 34 | - | expression tag |
Ile 35 | - | expression tag |
Gln 36 | - | expression tag |
Lys 37 | - | expression tag |
Tyr 38 | - | expression tag |
Leu 39 | - | expression tag |
Trp 146 | Cys 146 | engineered mutation |
Val 371 | - | expression tag |
Phe 372 | - | expression tag |
Thr 373 | - | expression tag |
Leu 374 | - | expression tag |
Glu 375 | - | expression tag |
Asp 376 | - | expression tag |
Phe 377 | - | expression tag |
Val 378 | - | expression tag |
Gly 379 | - | expression tag |
Asp 380 | - | expression tag |
Trp 381 | - | expression tag |
Glu 382 | - | expression tag |
Gln 383 | - | expression tag |
Thr 384 | - | expression tag |
Ala 385 | - | expression tag |
Ala 386 | - | expression tag |
Tyr 387 | - | expression tag |
Asn 388 | - | expression tag |
Leu 389 | - | expression tag |
Asp 390 | - | expression tag |
Gln 391 | - | expression tag |
Val 392 | - | expression tag |
Leu 393 | - | expression tag |
Glu 394 | - | expression tag |
Gln 395 | - | expression tag |
Gly 396 | - | expression tag |
Gly 397 | - | expression tag |
Val 398 | - | expression tag |
Ser 399 | - | expression tag |
Ser 400 | - | expression tag |
Leu 401 | - | expression tag |
Leu 402 | - | expression tag |
Gln 403 | - | expression tag |
Asn 404 | - | expression tag |
Leu 405 | - | expression tag |
Ala 406 | - | expression tag |
Val 407 | - | expression tag |
Ser 408 | - | expression tag |
Val 409 | - | expression tag |
Thr 410 | - | expression tag |
Pro 411 | - | expression tag |
Ile 412 | - | expression tag |
Gln 413 | - | expression tag |
Arg 414 | - | expression tag |
Ile 415 | - | expression tag |
Val 416 | - | expression tag |
Arg 417 | - | expression tag |
Ser 418 | - | expression tag |
Gly 419 | - | expression tag |
Glu 420 | - | expression tag |
Asn 421 | - | expression tag |
Ala 422 | - | expression tag |
Leu 423 | - | expression tag |
Lys 424 | - | expression tag |
Ile 425 | - | expression tag |
Asp 426 | - | expression tag |
Ile 427 | - | expression tag |
His 428 | - | expression tag |
Val 429 | - | expression tag |
Ile 430 | - | expression tag |
Ile 431 | - | expression tag |
Pro 432 | - | expression tag |
Tyr 433 | - | expression tag |
Glu 434 | - | expression tag |
Gly 435 | - | expression tag |
Leu 436 | - | expression tag |
Ser 437 | - | expression tag |
Ala 438 | - | expression tag |
Asp 439 | - | expression tag |
Gln 440 | - | expression tag |
Met 441 | - | expression tag |
Ala 442 | - | expression tag |
Gln 443 | - | expression tag |
Ile 444 | - | expression tag |
Glu 445 | - | expression tag |
Glu 446 | - | expression tag |
Val 447 | - | expression tag |
Phe 448 | - | expression tag |
Lys 449 | - | expression tag |
Val 450 | - | expression tag |
Val 451 | - | expression tag |
Tyr 452 | - | expression tag |
Pro 453 | - | expression tag |
Val 454 | - | expression tag |
Asp 455 | - | expression tag |
Asp 456 | - | expression tag |
His 457 | - | expression tag |
His 458 | - | expression tag |
Phe 459 | - | expression tag |
Lys 460 | - | expression tag |
Val 461 | - | expression tag |
Ile 462 | - | expression tag |
Leu 463 | - | expression tag |
Pro 464 | - | expression tag |
Tyr 465 | - | expression tag |
Gly 466 | - | expression tag |
Thr 467 | - | expression tag |
Leu 468 | - | expression tag |
Val 469 | - | expression tag |
Ile 470 | - | expression tag |
Asp 471 | - | expression tag |
Gly 472 | - | expression tag |
Val 473 | - | expression tag |
Thr 474 | - | expression tag |
Pro 475 | - | expression tag |
Asn 476 | - | expression tag |
Met 477 | - | expression tag |
Leu 478 | - | expression tag |
Asn 479 | - | expression tag |
Tyr 480 | - | expression tag |
Phe 481 | - | expression tag |
Gly 482 | - | expression tag |
Arg 483 | - | expression tag |
Pro 484 | - | expression tag |
Tyr 485 | - | expression tag |
Glu 486 | - | expression tag |
Gly 487 | - | expression tag |
Ile 488 | - | expression tag |
Ala 489 | - | expression tag |
Val 490 | - | expression tag |
Phe 491 | - | expression tag |
Asp 492 | - | expression tag |
Gly 493 | - | expression tag |
Lys 494 | - | expression tag |
Lys 495 | - | expression tag |
Ile 496 | - | expression tag |
Thr 497 | - | expression tag |
Val 498 | - | expression tag |
Thr 499 | - | expression tag |
Gly 500 | - | expression tag |
Thr 501 | - | expression tag |
Leu 502 | - | expression tag |
Trp 503 | - | expression tag |
Asn 504 | - | expression tag |
Gly 505 | - | expression tag |
Asn 506 | - | expression tag |
Lys 507 | - | expression tag |
Ile 508 | - | expression tag |
Ile 509 | - | expression tag |
Asp 510 | - | expression tag |
Glu 511 | - | expression tag |
Arg 512 | - | expression tag |
Leu 513 | - | expression tag |
Ile 514 | - | expression tag |
Thr 515 | - | expression tag |
Pro 516 | - | expression tag |
Asp 517 | - | expression tag |
Gly 518 | - | expression tag |
Ser 519 | - | expression tag |
Met 520 | - | expression tag |
Leu 521 | - | expression tag |
Phe 522 | - | expression tag |
Arg 523 | - | expression tag |
Val 524 | - | expression tag |
Thr 525 | - | expression tag |
Ile 526 | - | expression tag |
Asn 527 | - | expression tag |
Ser 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 185248.9 | |
All* | Total formula weight | 185248.9 |