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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7F2O

Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		G subunit q (Gi1-Gq chimeric)polymer36141724.41Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P54311)
Pfam (PF00400)		Rattus norvegicus (Rat)Transducin beta chain 1
3C
(D)		ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARGpolymer91062.21UniProt (by SIFTS) (P01042)Homo sapiens
4D
(R)		B2 bradykinin receptorpolymer59567152.91UniProt (P30411)
Pfam (PF00001)		Homo sapiens (Human)B2R,BK-2 receptor
5E
(S)		single Fab chain (svFv16)polymer24826392.41synthetic construct
6F
(Y)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)		Bos taurus (Bovine)G gamma-I
Sequence modifications
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -10-initiating methionine
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: 40 - 370 (UniProt: P30411)
PDBExternal DatabaseDetails
Ala -66-expression tag
Asp -65-expression tag
Leu -64-expression tag
Glu -63-expression tag
Asp -62-expression tag
Asn -61-expression tag
Trp -60-expression tag
Glu -59-expression tag
Thr -58-expression tag
Leu -57-expression tag
Asn -56-expression tag
Asp -55-expression tag
Asn -54-expression tag
Leu -53-expression tag
Lys -52-expression tag
Val -51-expression tag
Ile -50-expression tag
Glu -49-expression tag
Lys -48-expression tag
Ala -47-expression tag
Asp -46-expression tag
Asn -45-expression tag
Ala -44-expression tag
Ala -43-expression tag
Gln -42-expression tag
Val -41-expression tag
Lys -40-expression tag
Asp -39-expression tag
Ala -38-expression tag
Leu -37-expression tag
Thr -36-expression tag
Lys -35-expression tag
Met -34-expression tag
Arg -33-expression tag
Ala -32-expression tag
Ala -31-expression tag
Ala -30-expression tag
Leu -29-expression tag
Asp -28-expression tag
Ala -27-expression tag
Gln -26-expression tag
Lys -25-expression tag
Ala -24-expression tag
Thr -23-expression tag
Pro -22-expression tag
Pro -21-expression tag
Lys -20-expression tag
Leu -19-expression tag
Glu -18-expression tag
Asp -17-expression tag
Lys -16-expression tag
Ser -15-expression tag
Pro -14-expression tag
Asp -13-expression tag
Ser -12-expression tag
Pro -11-expression tag
Glu -10-expression tag
Met -9-expression tag
Lys -8-expression tag
Asp -7-expression tag
Phe -6-expression tag
Arg -5-expression tag
His -4-expression tag
Gly -3-expression tag
Phe -2-expression tag
Asp -1-expression tag
Ile 0-expression tag
Leu 1-expression tag
Val 2-expression tag
Gly 3-expression tag
Gln 4-expression tag
Ile 5-expression tag
Asp 6-expression tag
Asp 7-expression tag
Ala 8-expression tag
Leu 9-expression tag
Lys 10-expression tag
Leu 11-expression tag
Ala 12-expression tag
Asn 13-expression tag
Glu 14-expression tag
Gly 15-expression tag
Lys 16-expression tag
Val 17-expression tag
Lys 18-expression tag
Glu 19-expression tag
Ala 20-expression tag
Gln 21-expression tag
Ala 22-expression tag
Ala 23-expression tag
Ala 24-expression tag
Glu 25-expression tag
Gln 26-expression tag
Leu 27-expression tag
Lys 28-expression tag
Thr 29-expression tag
Thr 30-expression tag
Arg 31-expression tag
Asn 32-expression tag
Ala 33-expression tag
Tyr 34-expression tag
Ile 35-expression tag
Gln 36-expression tag
Lys 37-expression tag
Tyr 38-expression tag
Leu 39-expression tag
Trp 146Cys 146engineered mutation
Val 371-expression tag
Phe 372-expression tag
Thr 373-expression tag
Leu 374-expression tag
Glu 375-expression tag
Asp 376-expression tag
Phe 377-expression tag
Val 378-expression tag
Gly 379-expression tag
Asp 380-expression tag
Trp 381-expression tag
Glu 382-expression tag
Gln 383-expression tag
Thr 384-expression tag
Ala 385-expression tag
Ala 386-expression tag
Tyr 387-expression tag
Asn 388-expression tag
Leu 389-expression tag
Asp 390-expression tag
Gln 391-expression tag
Val 392-expression tag
Leu 393-expression tag
Glu 394-expression tag
Gln 395-expression tag
Gly 396-expression tag
Gly 397-expression tag
Val 398-expression tag
Ser 399-expression tag
Ser 400-expression tag
Leu 401-expression tag
Leu 402-expression tag
Gln 403-expression tag
Asn 404-expression tag
Leu 405-expression tag
Ala 406-expression tag
Val 407-expression tag
Ser 408-expression tag
Val 409-expression tag
Thr 410-expression tag
Pro 411-expression tag
Ile 412-expression tag
Gln 413-expression tag
Arg 414-expression tag
Ile 415-expression tag
Val 416-expression tag
Arg 417-expression tag
Ser 418-expression tag
Gly 419-expression tag
Glu 420-expression tag
Asn 421-expression tag
Ala 422-expression tag
Leu 423-expression tag
Lys 424-expression tag
Ile 425-expression tag
Asp 426-expression tag
Ile 427-expression tag
His 428-expression tag
Val 429-expression tag
Ile 430-expression tag
Ile 431-expression tag
Pro 432-expression tag
Tyr 433-expression tag
Glu 434-expression tag
Gly 435-expression tag
Leu 436-expression tag
Ser 437-expression tag
Ala 438-expression tag
Asp 439-expression tag
Gln 440-expression tag
Met 441-expression tag
Ala 442-expression tag
Gln 443-expression tag
Ile 444-expression tag
Glu 445-expression tag
Glu 446-expression tag
Val 447-expression tag
Phe 448-expression tag
Lys 449-expression tag
Val 450-expression tag
Val 451-expression tag
Tyr 452-expression tag
Pro 453-expression tag
Val 454-expression tag
Asp 455-expression tag
Asp 456-expression tag
His 457-expression tag
His 458-expression tag
Phe 459-expression tag
Lys 460-expression tag
Val 461-expression tag
Ile 462-expression tag
Leu 463-expression tag
Pro 464-expression tag
Tyr 465-expression tag
Gly 466-expression tag
Thr 467-expression tag
Leu 468-expression tag
Val 469-expression tag
Ile 470-expression tag
Asp 471-expression tag
Gly 472-expression tag
Val 473-expression tag
Thr 474-expression tag
Pro 475-expression tag
Asn 476-expression tag
Met 477-expression tag
Leu 478-expression tag
Asn 479-expression tag
Tyr 480-expression tag
Phe 481-expression tag
Gly 482-expression tag
Arg 483-expression tag
Pro 484-expression tag
Tyr 485-expression tag
Glu 486-expression tag
Gly 487-expression tag
Ile 488-expression tag
Ala 489-expression tag
Val 490-expression tag
Phe 491-expression tag
Asp 492-expression tag
Gly 493-expression tag
Lys 494-expression tag
Lys 495-expression tag
Ile 496-expression tag
Thr 497-expression tag
Val 498-expression tag
Thr 499-expression tag
Gly 500-expression tag
Thr 501-expression tag
Leu 502-expression tag
Trp 503-expression tag
Asn 504-expression tag
Gly 505-expression tag
Asn 506-expression tag
Lys 507-expression tag
Ile 508-expression tag
Ile 509-expression tag
Asp 510-expression tag
Glu 511-expression tag
Arg 512-expression tag
Leu 513-expression tag
Ile 514-expression tag
Thr 515-expression tag
Pro 516-expression tag
Asp 517-expression tag
Gly 518-expression tag
Ser 519-expression tag
Met 520-expression tag
Leu 521-expression tag
Phe 522-expression tag
Arg 523-expression tag
Val 524-expression tag
Thr 525-expression tag
Ile 526-expression tag
Asn 527-expression tag
Ser 528-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight185248.9
All*Total formula weight185248.9
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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