7F1S
Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | C-C chemokine receptor type 5 | polymer | 367 | 42028.1 | 1 | UniProt (P51681) Pfam (PF00001) | Homo sapiens (Human) | C-C CKR-5,CC-CKR-5,CCR-5,CCR5,CHEMR13,HIV-1 fusion coreceptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40447.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
Sequence modifications
R: 2 - 319 (UniProt: P51681)
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Asn 163 | Gly 163 | engineered mutation |
| Leu 320 | - | expression tag |
| Glu 321 | - | expression tag |
| Val 322 | - | expression tag |
| Leu 323 | - | expression tag |
| Phe 324 | - | expression tag |
| Gln 325 | - | expression tag |
| Gly 326 | - | expression tag |
| Pro 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Ser 329 | - | expression tag |
| Trp 330 | - | expression tag |
| Ser 331 | - | expression tag |
| His 332 | - | expression tag |
| Pro 333 | - | expression tag |
| Gln 334 | - | expression tag |
| Phe 335 | - | expression tag |
| Glu 336 | - | expression tag |
| Lys 337 | - | expression tag |
| Gly 338 | - | expression tag |
| Ser 339 | - | expression tag |
| Gly 340 | - | expression tag |
| Ala 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Ala 343 | - | expression tag |
| Ser 344 | - | expression tag |
| Ala 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Trp 348 | - | expression tag |
| Ser 349 | - | expression tag |
| His 350 | - | expression tag |
| Pro 351 | - | expression tag |
| Gln 352 | - | expression tag |
| Phe 353 | - | expression tag |
| Glu 354 | - | expression tag |
| Lys 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Asp 358 | - | expression tag |
| Tyr 359 | - | expression tag |
| Lys 360 | - | expression tag |
| Asp 361 | - | expression tag |
| Asp 362 | - | expression tag |
| Asp 363 | - | expression tag |
| Asp 364 | - | expression tag |
| Lys 365 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Ser 47 | engineered mutation |
| Thr 202 | Gly 202 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127753.3 | |
| All* | Total formula weight | 127753.3 |
