7F1G
BACE2 xaperone complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-secretase 2 | polymer | 386 | 42105.4 | 1 | UniProt (Q9Y5Z0) Pfam (PF00026) | Homo sapiens (Human) | Aspartic-like protease 56 kDa,Aspartyl protease 1,Asp 1,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Down region aspartic protease,DRAP,Memapsin-1,Membrane-associated aspartic protease 1,Theta-secretase |
| 2 | B (D) | XAPERONE | polymer | 113 | 11968.3 | 1 | Homo sapiens | ||
| 3 | C (A) | N-[3-[(4R,5R,6R)-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide | non-polymer | 434.5 | 1 | Chemie (0QQ) | |||
| 4 | D, E (A, D) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54073.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 54508.1 |
