7F0W
Crystal structure of KRAS-G12D bound to GDP with switch 1 open conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Isoform 2B of GTPase KRas | polymer | 169 | 19285.7 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 2 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19285.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.5 | |
| All* | Total formula weight | 19753.2 |
