7ESF

The Crystal Structure of human MTH1 from Biortus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	7,8-dihydro-8-oxoguanine triphosphatase	polymer	174	20071.7	1	UniProt (P36639) Pfam (PF00293)	Homo sapiens (Human)	2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1
2	B (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
3	C (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
4	D (A)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

A: 42 - 197 (UniProt: P36639)

PDB	External Database	Details
Met 24	-	initiating methionine
Gly 25	-	expression tag
Ser 26	-	expression tag
Ser 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
Glu 34	-	expression tag
Asn 35	-	expression tag
Leu 36	-	expression tag
Tyr 37	-	expression tag
Phe 38	-	expression tag
Gln 39	-	expression tag
Gly 40	-	expression tag
Gly 41	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20071.7
Non-Polymers*	Number of molecules	2
	Total formula weight	300.3
All*	Total formula weight	20372.1

*Water molecules are not included.