7ESE
The Crystal Structure of human DHFR from Biortus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 204 | 23493.9 | 1 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (Human) | |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C (A) | FOLIC ACID | non-polymer | 441.4 | 1 | Chemie (FOL) | |||
| 4 | D (A) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 1 - 187 (UniProt: P00374)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| Gly -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Ser -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23493.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1184.8 | |
| All* | Total formula weight | 24678.7 |
