7EOR
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Glutamate receptor ionotropic, NMDA 2A | polymer | 853 | 95537.7 | 2 | UniProt (Q12879) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A,hNR2A |
2 | B, D | Glutamate receptor ionotropic, NMDA 1 | polymer | 847 | 95210.1 | 2 | UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
3 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
4 | A, C | 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one | non-polymer | 360.4 | 2 | Chemie (6RM) |
Sequence modifications
A, C: 1 - 842 (UniProt: Q12879)
B, D: 1 - 847 (UniProt: Q05586)
PDB | External Database | Details |
---|---|---|
Cys 794 | Leu 794 | engineered mutation |
Lys 843 | - | expression tag |
Ser 844 | - | expression tag |
Arg 845 | - | expression tag |
Ala 846 | - | expression tag |
Glu 847 | - | expression tag |
Ala 848 | - | expression tag |
Lys 849 | - | expression tag |
Arg 850 | - | expression tag |
Met 851 | - | expression tag |
Lys 852 | - | expression tag |
Gly 853 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 698 | Glu 698 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 381495.6 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 3817.7 | |
All* | Total formula weight | 385313.3 |