7EOQ

Structure of the human GluN1/GluN2A NMDA receptor in the glycine/CPP bound state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Glutamate receptor ionotropic, NMDA 2A	polymer	853	95537.7	2	UniProt (Q12879) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A,hNR2A
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 1	polymer	847	95210.1	2	UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
3	E, G, H, I, J... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
4	F, K (A, C)	(2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid	non-polymer		252.2	2	Chemie (7RC)

Sequence modifications

A, C: 1 - 842 (UniProt: Q12879)

PDB	External Database	Details
Cys 794	Leu 794	engineered mutation
Lys 843	-	expression tag
Ser 844	-	expression tag
Arg 845	-	expression tag
Ala 846	-	expression tag
Glu 847	-	expression tag
Ala 848	-	expression tag
Lys 849	-	expression tag
Arg 850	-	expression tag
Met 851	-	expression tag
Lys 852	-	expression tag
Gly 853	-	expression tag

B, D: 1 - 847 (UniProt: Q05586)

PDB	External Database	Details
Cys 698	Glu 698	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	381495.6
Non-Polymers*	Number of molecules	10
	Total formula weight	2274.1
All*	Total formula weight	383769.7

*Water molecules are not included.