7EJ8
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 354 | 40100.5 | 1 | UniProt (P09471) Pfam (PF00503) In PDB | Homo sapiens (Human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 349 | 38402.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | R | Alpha-2A adrenergic receptor | polymer | 465 | 50704.6 | 1 | UniProt (P08913) Pfam (PF00001) In PDB | Homo sapiens (Human) | Alpha-2 adrenergic receptor subtype C10,Alpha-2A adrenoreceptor,Alpha-2A adrenoceptor,Alpha-2AAR |
5 | H | scFv16 | polymer | 307 | 32898.8 | 1 | Mus musculus (mouse) | ||
6 | R | Brimonidine | non-polymer | 292.1 | 1 | Chemie (J59) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 169967.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 292.1 | |
All* | Total formula weight | 170260.0 |