7EJ8
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 354 | 40100.5 | 1 | UniProt (P09471) Pfam (PF00503) | Homo sapiens (Human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 349 | 38402.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (R) | Alpha-2A adrenergic receptor | polymer | 465 | 50704.6 | 1 | UniProt (P08913) Pfam (PF00001) | Homo sapiens (Human) | Alpha-2 adrenergic receptor subtype C10,Alpha-2A adrenoreceptor,Alpha-2A adrenoceptor,Alpha-2AAR |
| 5 | E (H) | scFv16 | polymer | 307 | 32898.8 | 1 | Mus musculus (mouse) | ||
| 6 | F (R) | Brimonidine | non-polymer | 292.1 | 1 | Chemie (J59) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 169967.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 292.1 | |
| All* | Total formula weight | 170260.0 |
