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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7EIB

Cryo-EM structure of the type 1 bradykinin receptor in complex with the des-Arg10-kallidin and an Gq protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		B1 bradykinin receptorpolymer61369344.11UniProt (P46663)
Pfam (PF00001)		Homo sapiens (Human)B1R,BK-1 receptor
2B
(D)		LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHEpolymer91034.21UniProt (by SIFTS) (P01042)Homo sapiens
3C
(B)		G subunit q (Gi1-Gq chimeric)polymer36141724.41Homo sapiens
4D
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P54311)
Pfam (PF00400)		Rattus norvegicus (Rat)Transducin beta chain 1
5E
(E)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)		Bos taurus (Bovine)G gamma-I
Sequence modifications
A: 2 - 350 (UniProt: P46663)
PDBExternal DatabaseDetails
Ala -104-expression tag
Asp -103-expression tag
Leu -102-expression tag
Glu -101-expression tag
Asp -100-expression tag
Asn -99-expression tag
Trp -98-expression tag
Glu -97-expression tag
Thr -96-expression tag
Leu -95-expression tag
Asn -94-expression tag
Asp -93-expression tag
Asn -92-expression tag
Leu -91-expression tag
Lys -90-expression tag
Val -89-expression tag
Ile -88-expression tag
Glu -87-expression tag
Lys -86-expression tag
Ala -85-expression tag
Asp -84-expression tag
Asn -83-expression tag
Ala -82-expression tag
Ala -81-expression tag
Gln -80-expression tag
Val -79-expression tag
Lys -78-expression tag
Asp -77-expression tag
Ala -76-expression tag
Leu -75-expression tag
Thr -74-expression tag
Lys -73-expression tag
Met -72-expression tag
Arg -71-expression tag
Ala -70-expression tag
Ala -69-expression tag
Ala -68-expression tag
Leu -67-expression tag
Asp -66-expression tag
Ala -65-expression tag
Gln -64-expression tag
Lys -63-expression tag
Ala -62-expression tag
Thr -61-expression tag
Pro -60-expression tag
Pro -59-expression tag
Lys -58-expression tag
Leu -57-expression tag
Glu -56-expression tag
Asp -55-expression tag
Lys -54-expression tag
Ser -53-expression tag
Pro -52-expression tag
Asp -51-expression tag
Ser -50-expression tag
Pro -49-expression tag
Glu -48-expression tag
Met -47-expression tag
Lys -46-expression tag
Asp -45-expression tag
Phe -44-expression tag
Arg -43-expression tag
His -42-expression tag
Gly -41-expression tag
Phe -40-expression tag
Asp -39-expression tag
Ile -38-expression tag
Leu -37-expression tag
Val -36-expression tag
Gly -35-expression tag
Gln -34-expression tag
Ile -33-expression tag
Asp -32-expression tag
Asp -31-expression tag
Ala -30-expression tag
Leu -29-expression tag
Lys -28-expression tag
Leu -27-expression tag
Ala -26-expression tag
Asn -25-expression tag
Glu -24-expression tag
Gly -23-expression tag
Lys -22-expression tag
Val -21-expression tag
Lys -20-expression tag
Glu -19-expression tag
Ala -18-expression tag
Gln -17-expression tag
Ala -16-expression tag
Ala -15-expression tag
Ala -14-expression tag
Glu -13-expression tag
Gln -12-expression tag
Leu -11-expression tag
Lys -10-expression tag
Thr -9-expression tag
Thr -8-expression tag
Arg -7-expression tag
Asn -6-expression tag
Ala -5-expression tag
Tyr -4-expression tag
Ile -3-expression tag
Gln -2-expression tag
Lys -1-expression tag
Tyr 0-expression tag
Leu 1-expression tag
Trp 126Phe 126engineered mutation
Val 351-expression tag
Phe 352-expression tag
Thr 353-expression tag
Leu 354-expression tag
Glu 355-expression tag
Asp 356-expression tag
Phe 357-expression tag
Val 358-expression tag
Gly 359-expression tag
Asp 360-expression tag
Trp 361-expression tag
Glu 362-expression tag
Gln 363-expression tag
Thr 364-expression tag
Ala 365-expression tag
Ala 366-expression tag
Tyr 367-expression tag
Asn 368-expression tag
Leu 369-expression tag
Asp 370-expression tag
Gln 371-expression tag
Val 372-expression tag
Leu 373-expression tag
Glu 374-expression tag
Gln 375-expression tag
Gly 376-expression tag
Gly 377-expression tag
Val 378-expression tag
Ser 379-expression tag
Ser 380-expression tag
Leu 381-expression tag
Leu 382-expression tag
Gln 383-expression tag
Asn 384-expression tag
Leu 385-expression tag
Ala 386-expression tag
Val 387-expression tag
Ser 388-expression tag
Val 389-expression tag
Thr 390-expression tag
Pro 391-expression tag
Ile 392-expression tag
Gln 393-expression tag
Arg 394-expression tag
Ile 395-expression tag
Val 396-expression tag
Arg 397-expression tag
Ser 398-expression tag
Gly 399-expression tag
Glu 400-expression tag
Asn 401-expression tag
Ala 402-expression tag
Leu 403-expression tag
Lys 404-expression tag
Ile 405-expression tag
Asp 406-expression tag
Ile 407-expression tag
His 408-expression tag
Val 409-expression tag
Ile 410-expression tag
Ile 411-expression tag
Pro 412-expression tag
Tyr 413-expression tag
Glu 414-expression tag
Gly 415-expression tag
Leu 416-expression tag
Ser 417-expression tag
Ala 418-expression tag
Asp 419-expression tag
Gln 420-expression tag
Met 421-expression tag
Ala 422-expression tag
Gln 423-expression tag
Ile 424-expression tag
Glu 425-expression tag
Glu 426-expression tag
Val 427-expression tag
Phe 428-expression tag
Lys 429-expression tag
Val 430-expression tag
Val 431-expression tag
Tyr 432-expression tag
Pro 433-expression tag
Val 434-expression tag
Asp 435-expression tag
Asp 436-expression tag
His 437-expression tag
His 438-expression tag
Phe 439-expression tag
Lys 440-expression tag
Val 441-expression tag
Ile 442-expression tag
Leu 443-expression tag
Pro 444-expression tag
Tyr 445-expression tag
Gly 446-expression tag
Thr 447-expression tag
Leu 448-expression tag
Val 449-expression tag
Ile 450-expression tag
Asp 451-expression tag
Gly 452-expression tag
Val 453-expression tag
Thr 454-expression tag
Pro 455-expression tag
Asn 456-expression tag
Met 457-expression tag
Leu 458-expression tag
Asn 459-expression tag
Tyr 460-expression tag
Phe 461-expression tag
Gly 462-expression tag
Arg 463-expression tag
Pro 464-expression tag
Tyr 465-expression tag
Glu 466-expression tag
Gly 467-expression tag
Ile 468-expression tag
Ala 469-expression tag
Val 470-expression tag
Phe 471-expression tag
Asp 472-expression tag
Gly 473-expression tag
Lys 474-expression tag
Lys 475-expression tag
Ile 476-expression tag
Thr 477-expression tag
Val 478-expression tag
Thr 479-expression tag
Gly 480-expression tag
Thr 481-expression tag
Leu 482-expression tag
Trp 483-expression tag
Asn 484-expression tag
Gly 485-expression tag
Asn 486-expression tag
Lys 487-expression tag
Ile 488-expression tag
Ile 489-expression tag
Asp 490-expression tag
Glu 491-expression tag
Arg 492-expression tag
Leu 493-expression tag
Ile 494-expression tag
Thr 495-expression tag
Pro 496-expression tag
Asp 497-expression tag
Gly 498-expression tag
Ser 499-expression tag
Met 500-expression tag
Leu 501-expression tag
Phe 502-expression tag
Arg 503-expression tag
Val 504-expression tag
Thr 505-expression tag
Ile 506-expression tag
Asn 507-expression tag
Ser 508-expression tag
C: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -10-initiating methionine
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight161019.7
All*Total formula weight161019.7
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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