7EGV
Acetolactate Synthase from Trichoderma harzianum with inhibitor harzianic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Acetolactate synthase | polymer | 688 | 75026.6 | 2 | UniProt (A0A2N1LPC4) | Trichoderma harzianum | |
| 2 | C, M (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, N (A, B) | 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 440.3 | 2 | Chemie (TZD) | |||
| 4 | E, O (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 5 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | G (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | H, I, J, P, Q (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 8 | K (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 9 | L (B) | (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid | non-polymer | 365.4 | 1 | Chemie (J3L) | |||
| 10 | R, S (A, B) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A, B: 53 - 689 (UniProt: A0A2N1LPC4)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Val 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Arg 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Met 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Thr 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Ala 24 | - | expression tag |
| Ala 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Phe 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Arg 29 | - | expression tag |
| Gln 30 | - | expression tag |
| His 31 | - | expression tag |
| Met 32 | - | expression tag |
| Asp 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Pro 35 | - | expression tag |
| Asp 36 | - | expression tag |
| Leu 37 | - | expression tag |
| Gly 38 | - | expression tag |
| Thr 39 | - | expression tag |
| Asp 40 | - | expression tag |
| Asp 41 | - | expression tag |
| Asp 42 | - | expression tag |
| Asp 43 | - | expression tag |
| Lys 44 | - | expression tag |
| Ala 45 | - | expression tag |
| Met 46 | - | expression tag |
| Ala 47 | - | expression tag |
| Asp 48 | - | expression tag |
| Ile 49 | - | expression tag |
| Gly 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Met 52 | - | expression tag |
| Arg 602 | Lys 602 | engineered mutation |
| Ile 615 | Val 615 | engineered mutation |
| Val 627 | Ile 627 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 150053.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3473.2 | |
| All* | Total formula weight | 153526.5 |
