7EG0
Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | polymer | 434 | 49552.5 | 2 | UniProt (Q14432) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A |
| 2 | B, D (B, D) | Schlafen family member 12 | polymer | 567 | 65665.7 | 2 | UniProt (Q8IYM2) Pfam (PF17057) Pfam (PF04326) Pfam (PF21026) | Homo sapiens (Human) | |
| 3 | E, I (A, C) | 6,7-bis(chloranyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one | non-polymer | 256.1 | 2 | Chemie (J33) | |||
| 4 | F, G, J, K (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | H, L (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
B, D: 2 - 568 (UniProt: Q8IYM2)
| PDB | External Database | Details |
|---|---|---|
| Arg 213 | Lys 213 | engineered mutation |
| Ala 351 | Ser 351 | engineered mutation |
| Ser 415 | Asp 415 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 230436.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 740.2 | |
| All* | Total formula weight | 231176.6 |
