7EFR
Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Processed angiotensin-converting enzyme 2 | polymer | 599 | 69474.0 | 1 | UniProt (Q9BYF1) Pfam (PF01401) | Homo sapiens (Human) | |
| 2 | B (B) | Spike glycoprotein | polymer | 217 | 24402.5 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | S glycoprotein,E2,Peplomer protein |
| 3 | C, D, E, F, G (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 19 - 615 (UniProt: Q9BYF1)
| PDB | External Database | Details |
|---|---|---|
| Ala 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Trp 27 | Thr 27 | engineered mutation |
| Tyr 330 | Asn 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93876.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 94982.5 |
