7EFM
Crystal structure of the gastric proton pump K791S/E820D/Y340N in (BYK)E2BeF state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha | polymer | 987 | 109092.5 | 1 | UniProt (A0A5G2QYH2) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF08282) Pfam (PF00689) UniProt (by SIFTS) (P19156) | Sus scrofa (Pig) | |
| 2 | B (B) | Potassium-transporting ATPase subunit beta | polymer | 261 | 29630.9 | 1 | UniProt (P18434) Pfam (PF00287) | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90 |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D, E, G (A) | RUBIDIUM ION | non-polymer | 85.5 | 3 | Chemie (RB) PubChem (105153) | |||
| 5 | F (A) | (7R,8R,9S)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol | non-polymer | 309.4 | 1 | Chemie (J3C) PubChem (156587317) | |||
| 6 | H (A) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
| 7 | I, J, K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A: 48 - 1033 (UniProt: A0A5G2QYH2)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Asn 340 | Tyr 348 | engineered mutation |
| Ser 791 | Lys 799 | engineered mutation |
| Asp 820 | Glu 828 | engineered mutation |
| Ser 1005 | Gly 1013 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 138723.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1319.7 | |
| All* | Total formula weight | 140043.1 |
