7EDS
Human p53 core domain with germline hot spot mutation M133T in complex with the natural PIG3 p53-response element and Arsenic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cellular tumor antigen p53 | polymer | 200 | 22475.5 | 1 | UniProt (P04637) Pfam (PF00870) In PDB | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | R | PIG3 sense strand | polymer | 30 | 9306.0 | 1 | Homo sapiens | ||
| 3 | F | PIG3 anti-sense strand | polymer | 30 | 9145.9 | 1 | Homo sapiens | ||
| 4 | A | ARSENIC | non-polymer | 74.9 | 1 | Chemie (ARS) | |||
| 5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Thr 133 | Met 133 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 40927.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 140.3 | |
| All* | Total formula weight | 41067.7 |
