7EBB
Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | polymer | 404 | 45598.9 | 2 | UniProt (Q16654) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 4 |
| 2 | C, E, F, G, J (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | D (A) | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | non-polymer | 143.1 | 1 | Chemie (42A) | |||
| 4 | H (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | I (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 411 (UniProt: Q16654)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Pro 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91197.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1075.0 | |
| All* | Total formula weight | 92272.7 |
