7EB2
Cryo-EM structure of human GABA(B) receptor-Gi protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | N | ScFv16 | polymer | 269 | 28813.0 | 1 | synthetic construct | ||
5 | C | Gamma-aminobutyric acid type B receptor subunit 1 | polymer | 937 | 105976.3 | 1 | UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003) Pfam (PF00084) In PDB | Homo sapiens (Human) | Gb1 |
6 | D | Gamma-aminobutyric acid type B receptor subunit 2 | polymer | 808 | 91359.4 | 1 | UniProt (O75899) Pfam (PF01094) Pfam (PF00003) Pfam (PF18455) In PDB | Homo sapiens (Human) | Gb2,G-protein coupled receptor 51,HG20 |
7 | C | baclofen | non-polymer | 213.7 | 1 | Chemie (2C0) | |||
8 | D | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one | non-polymer | 330.3 | 1 | Chemie (FN0) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
C: 15 - 919 (UniProt: Q9UBS5)
D: 41 - 819 (UniProt: O75899)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Lys 0 | - | expression tag |
Thr 1 | - | expression tag |
Ile 2 | - | expression tag |
Ile 3 | - | expression tag |
Ala 4 | - | expression tag |
Leu 5 | - | expression tag |
Ser 6 | - | expression tag |
Tyr 7 | - | expression tag |
Ile 8 | - | expression tag |
Phe 9 | - | expression tag |
Cys 10 | - | expression tag |
Leu 11 | - | expression tag |
Val 12 | - | expression tag |
Phe 13 | - | expression tag |
Ala 14 | - | expression tag |
Leu 920 | - | expression tag |
Glu 921 | - | expression tag |
Val 922 | - | expression tag |
Leu 923 | - | expression tag |
Phe 924 | - | expression tag |
Gln 925 | - | expression tag |
Gly 926 | - | expression tag |
Pro 927 | - | expression tag |
His 928 | - | expression tag |
His 929 | - | expression tag |
His 930 | - | expression tag |
His 931 | - | expression tag |
His 932 | - | expression tag |
His 933 | - | expression tag |
His 934 | - | expression tag |
His 935 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 12 | - | initiating methionine |
Lys 13 | - | expression tag |
Thr 14 | - | expression tag |
Ile 15 | - | expression tag |
Ile 16 | - | expression tag |
Ala 17 | - | expression tag |
Leu 18 | - | expression tag |
Ser 19 | - | expression tag |
Tyr 20 | - | expression tag |
Ile 21 | - | expression tag |
Phe 22 | - | expression tag |
Cys 23 | - | expression tag |
Leu 24 | - | expression tag |
Val 25 | - | expression tag |
Phe 26 | - | expression tag |
Ala 27 | - | expression tag |
Asp 28 | - | expression tag |
Tyr 29 | - | expression tag |
Lys 30 | - | expression tag |
Asp 31 | - | expression tag |
Asp 32 | - | expression tag |
Asp 33 | - | expression tag |
Asp 34 | - | expression tag |
Lys 35 | - | expression tag |
Gly 36 | - | expression tag |
Ser 37 | - | expression tag |
Gly 38 | - | expression tag |
Gly 39 | - | expression tag |
Ser 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 313842.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 544.0 | |
All* | Total formula weight | 314386.1 |