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7EAS

Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrialpolymer39444647.71UniProt (Q15119)
Pfam (PF10436)
Pfam (PF02518)
Homo sapiens (Human)Pyruvate dehydrogenase kinase isoform 2,PDH kinase 2,PDKII
2B
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
3C, D
(A)
ACETATE IONnon-polymer59.02Chemie (ACT)
4E, F
(A)
DIMETHYL SULFOXIDEnon-polymer78.12Chemie (DMS)
5G
(A)
1H-pyrrolo[2,3-b]pyridine-3-carbonitrilenon-polymer143.11Chemie (42A)
6H
(A)
waterwater18.084Chemie (HOH)
Sequence modifications
A: 16 - 407 (UniProt: Q15119)
PDBExternal DatabaseDetails
Gly 14-expression tag
Ser 15-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight44647.7
Non-Polymers*Number of molecules6
Total formula weight453.0
All*Total formula weight45100.7
*Water molecules are not included.

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PDB entries from 2025-07-30

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