7EA5
Yeast Set2 bound to a nucleosome containing oncohistone mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 101 | 11847.9 | 2 | UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P84233) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 78 | 8853.3 | 2 | Pfam (PF15511) UniProt (by SIFTS) (P62799) | Xenopus laevis | |
| 3 | C, G (C, G) | Histone H2A | polymer | 105 | 11494.4 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (D, H) | Histone H2B | polymer | 93 | 10407.0 | 2 | UniProt (A0A1L8FQA5) Pfam (PF00125) UniProt (by SIFTS) (P02281) | Xenopus laevis (African clawed frog) | |
| 5 | I (I) | 601-DNA | polymer | 145 | 44521.4 | 1 | synthetic construct | ||
| 6 | J (J) | 601-DNA | polymer | 145 | 44992.6 | 1 | synthetic construct | ||
| 7 | K (K) | Histone-lysine N-methyltransferase, H3 lysine-36 specific | polymer | 228 | 26699.0 | 1 | UniProt (A0A6V8RR65) Pfam (PF17907) Pfam (PF00856) UniProt (by SIFTS) (P46995) | Saccharomyces cerevisiae (Baker's yeast) | SET domain-containing protein 2 |
| 8 | L, M, N (K) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 9 | O (K) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) |
Sequence modifications
A, E: 34 - 134 (UniProt: A0A310TTQ1)
| PDB | External Database | Details |
|---|---|---|
| Met 36 | Lys 37 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 201418.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 594.7 | |
| All* | Total formula weight | 202012.9 |
