7EA5

Yeast Set2 bound to a nucleosome containing oncohistone mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Histone H3	polymer	101	11847.9	2	UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P84233)	Xenopus laevis (African clawed frog)
2	B, F (B, F)	Histone H4	polymer	78	8853.3	2	Pfam (PF15511) UniProt (by SIFTS) (P62799)	Xenopus laevis
3	C, G (C, G)	Histone H2A	polymer	105	11494.4	2	UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211)	Xenopus laevis (African clawed frog)
4	D, H (D, H)	Histone H2B	polymer	93	10407.0	2	UniProt (A0A1L8FQA5) Pfam (PF00125) UniProt (by SIFTS) (P02281)	Xenopus laevis (African clawed frog)
5	I (I)	601-DNA	polymer	145	44521.4	1		synthetic construct
6	J (J)	601-DNA	polymer	145	44992.6	1		synthetic construct
7	K (K)	Histone-lysine N-methyltransferase, H3 lysine-36 specific	polymer	228	26699.0	1	UniProt (A0A6V8RR65) Pfam (PF17907) Pfam (PF00856) UniProt (by SIFTS) (P46995)	Saccharomyces cerevisiae (Baker's yeast)	SET domain-containing protein 2
8	L, M, N (K)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
9	O (K)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094)

Sequence modifications

A, E: 34 - 134 (UniProt: A0A310TTQ1)

PDB	External Database	Details
Met 36	Lys 37	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	201418.2
Non-Polymers*	Number of molecules	4
	Total formula weight	594.7
All*	Total formula weight	202012.9

*Water molecules are not included.