7E8E

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, transmembrane and intracellular region

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, E	Kv channel-interacting protein 1	polymer	181	21242.9	2	UniProt (Q9NZI2) Pfam (PF13833) Pfam (PF13499) In PDB	Homo sapiens (Human)	KChIP1,A-type potassium channel modulatory protein 1,Potassium channel-interacting protein 1,Vesicle APC-binding protein
2	C, D, A, B	Potassium voltage-gated channel subfamily D member 2	polymer	494	55755.7	4	UniProt (Q9NZV8) Pfam (PF11601) Pfam (PF02214) Pfam (PF00520) Pfam (PF07885) Pfam (PF11879) In PDB	Homo sapiens (Human)	Voltage-gated potassium channel subunit Kv4.2
3	K, I	Dipeptidyl aminopeptidase-like protein 6	polymer	31	3032.8	2	UniProt (P42658) In PDB	Homo sapiens (Human)	DPPX,Dipeptidyl aminopeptidase-related protein,Dipeptidyl peptidase 6,Dipeptidyl peptidase IV-like protein,Dipeptidyl peptidase VI,DPP VI
4	H, F	Kv channel-interacting protein 1	polymer	180	21145.8	2	UniProt (Q9NZI2) Pfam (PF13833) Pfam (PF13499) In PDB	Homo sapiens (Human)	KChIP1,A-type potassium channel modulatory protein 1,Potassium channel-interacting protein 1,Vesicle APC-binding protein
5	L, J	Dipeptidyl aminopeptidase-like protein 6	polymer	28	2819.6	2	UniProt (P42658) In PDB	Homo sapiens (Human)	DPPX,Dipeptidyl aminopeptidase-related protein,Dipeptidyl peptidase 6,Dipeptidyl peptidase IV-like protein,Dipeptidyl peptidase VI,DPP VI

Sequence modifications

C, D, A, B: 2 - 495 (UniProt: Q9NZV8)

PDB	External Database	Details
Ser 450	Asn 450	conflict

K, I: 32 - 58 (UniProt: P42658)

PDB	External Database	Details
Ala 28	-	expression tag
Ala 29	-	expression tag
Ala 30	-	expression tag
Ala 31	-	expression tag

L, J: 32 - 58 (UniProt: P42658)

PDB	External Database	Details
Ala 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	319505.3
All*	Total formula weight	319505.3

*Water molecules are not included.