7E7Q
Cryo-EM structure of human ABCA4 in ATP-bound state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Retinal-specific phospholipid-transporting ATPase ABCA4 | polymer | 2317 | 261141.6 | 1 | UniProt (P78363) Pfam (PF12698) Pfam (PF00005) In PDB | Homo sapiens (Human) | ATP-binding cassette sub-family A member 4,RIM ABC transporter,RIM protein,RmP,Retinal-specific ATP-binding cassette transporter,Stargardt disease protein |
2 | D, M | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G89225LT) | |||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
4 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: 1 - 2273 (UniProt: P78363)
PDB | External Database | Details |
---|---|---|
Met -20 | - | expression tag |
Ala -19 | - | expression tag |
Asp -18 | - | expression tag |
Tyr -17 | - | expression tag |
Lys -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Lys -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Pro -8 | - | expression tag |
Asp -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Asp -4 | - | expression tag |
Ala -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Gln 1087 | Glu 1087 | engineered mutation |
Gln 2096 | Glu 2096 | engineered mutation |
Leu 2274 | - | expression tag |
Glu 2275 | - | expression tag |
Gly 2276 | - | expression tag |
Ser 2277 | - | expression tag |
Asp 2278 | - | expression tag |
Glu 2279 | - | expression tag |
Val 2280 | - | expression tag |
Asp 2281 | - | expression tag |
Ala 2282 | - | expression tag |
Val 2283 | - | expression tag |
Glu 2284 | - | expression tag |
Gly 2285 | - | expression tag |
Ser 2286 | - | expression tag |
His 2287 | - | expression tag |
His 2288 | - | expression tag |
His 2289 | - | expression tag |
His 2290 | - | expression tag |
His 2291 | - | expression tag |
His 2292 | - | expression tag |
His 2293 | - | expression tag |
His 2294 | - | expression tag |
His 2295 | - | expression tag |
His 2296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 261141.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 1821.6 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 2611.4 | |
All* | Total formula weight | 265574.7 |