7E7O
Cryo-EM structure of human ABCA4 in NRPE-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinal-specific phospholipid-transporting ATPase ABCA4 | polymer | 2317 | 261143.5 | 1 | UniProt (P78363) Pfam (PF12698) Pfam (PF00005) | Homo sapiens (Human) | ATP-binding cassette sub-family A member 4,RIM ABC transporter,RIM protein,RmP,Retinal-specific ATP-binding cassette transporter,Stargardt disease protein |
| 2 | B, C (E, N) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G89225LT) | |||
| 3 | D, E, F, G, H... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 4 | K, L, M (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 3 | Chemie (3PE) | |||
| 5 | N (A) | [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate | non-polymer | 1010.5 | 1 | Chemie (HZL) |
Sequence modifications
A: 1 - 2273 (UniProt: P78363)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Lys -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Lys -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Leu 2274 | - | expression tag |
| Glu 2275 | - | expression tag |
| Gly 2276 | - | expression tag |
| Ser 2277 | - | expression tag |
| Asp 2278 | - | expression tag |
| Glu 2279 | - | expression tag |
| Val 2280 | - | expression tag |
| Asp 2281 | - | expression tag |
| Ala 2282 | - | expression tag |
| Val 2283 | - | expression tag |
| Glu 2284 | - | expression tag |
| Gly 2285 | - | expression tag |
| Ser 2286 | - | expression tag |
| His 2287 | - | expression tag |
| His 2288 | - | expression tag |
| His 2289 | - | expression tag |
| His 2290 | - | expression tag |
| His 2291 | - | expression tag |
| His 2292 | - | expression tag |
| His 2293 | - | expression tag |
| His 2294 | - | expression tag |
| His 2295 | - | expression tag |
| His 2296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 261143.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 4803.1 | |
| All* | Total formula weight | 267768.3 |
