7E72
Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | the chimeric Fab fragment of 3H7 (heavy chain) | polymer | 227 | 24388.4 | 2 | Homo sapiens | ||
| 2 | B, D (B, D) | the chimeric Fab fragment of 3H7 (light chain) | polymer | 214 | 23415.9 | 2 | Homo sapiens | ||
| 3 | E, F (E, F) | Angiopoietin-1 receptor | polymer | 199 | 22356.0 | 2 | UniProt (Q02763) Pfam (PF00041) | Homo sapiens (Human) | Endothelial tyrosine kinase,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,hTIE2,p140 TEK |
| 4 | AA, BA, CA, DA, EA... (B, C, A, D, E...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 34 | Chemie (EDO) | |||
| 5 | OA, PA, QA, RA, SA... (A, B, C, D, E...) | water | water | 18.0 | 737 | Chemie (HOH) |
Sequence modifications
E, F: 541 - 735 (UniProt: Q02763)
| PDB | External Database | Details |
|---|---|---|
| Gly 537 | - | expression tag |
| Ser 538 | - | expression tag |
| His 539 | - | expression tag |
| Met 540 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 140320.4 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 2110.3 | |
| All* | Total formula weight | 142430.7 |
