7E5S

SARS-CoV-2 S trimer with four-antibody cocktail complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein	polymer	1281	141437.4	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
2	D, F (D, H)	H014 light chain	polymer	210	23289.0	2		Homo sapiens
3	E, J (E, L)	H014 heavy chain	polymer	223	23823.6	2		Homo sapiens
4	G, H (I, J)	P17 heavy chain	polymer	120	13165.7	2		Homo sapiens
5	I, Q (K, T)	P17 light chain	polymer	108	11622.8	2		Homo sapiens
6	K, N, P (N, Q, S)	FC05 light chain	polymer	109	11217.4	3		Homo sapiens
7	L (O)	HB27 light chain	polymer	111	12050.4	1		Homo sapiens
8	M, R, S (P, U, V)	FC05 heavy chain	polymer	120	13289.7	3		Homo sapiens
9	O (R)	HB27 heavy chain	polymer	223	23614.5	1		Homo sapiens
10	AA, BA, CA, DA, EA... (a, b, c, d, e...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	12	In PDB GlyTouCan (G42666HT)

Sequence modifications

A, B, C: 1 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	engineered mutation
Ser 683	Arg 683	engineered mutation
Ser 685	Arg 685	engineered mutation
Pro 986	Lys 986	engineered mutation
Pro 987	Val 987	engineered mutation
Gly 1209	-	expression tag
Gly 1210	-	expression tag
Arg 1211	-	expression tag
Gly 1212	-	expression tag
Ser 1213	-	expression tag
Gly 1214	-	expression tag
Tyr 1215	-	expression tag
Ile 1216	-	expression tag
Pro 1217	-	expression tag
Glu 1218	-	expression tag
Ala 1219	-	expression tag
Pro 1220	-	expression tag
Arg 1221	-	expression tag
Asp 1222	-	expression tag
Gly 1223	-	expression tag
Gln 1224	-	expression tag
Ala 1225	-	expression tag
Tyr 1226	-	expression tag
Val 1227	-	expression tag
Arg 1228	-	expression tag
Lys 1229	-	expression tag
Asp 1230	-	expression tag
Gly 1231	-	expression tag
Glu 1232	-	expression tag
Trp 1233	-	expression tag
Val 1234	-	expression tag
Leu 1235	-	expression tag
Leu 1236	-	expression tag
Ser 1237	-	expression tag
Thr 1238	-	expression tag
Phe 1239	-	expression tag
Leu 1240	-	expression tag
Gly 1241	-	expression tag
Arg 1242	-	expression tag
Ser 1243	-	expression tag
Leu 1244	-	expression tag
Glu 1245	-	expression tag
Val 1246	-	expression tag
Leu 1247	-	expression tag
Phe 1248	-	expression tag
Gln 1249	-	expression tag
Gly 1250	-	expression tag
Pro 1251	-	expression tag
Gly 1252	-	expression tag
Trp 1253	-	expression tag
Ser 1254	-	expression tag
His 1255	-	expression tag
Pro 1256	-	expression tag
Gln 1257	-	expression tag
Phe 1258	-	expression tag
Glu 1259	-	expression tag
Lys 1260	-	expression tag
Gly 1261	-	expression tag
Gly 1262	-	expression tag
Gly 1263	-	expression tag
Ser 1264	-	expression tag
Gly 1265	-	expression tag
Gly 1266	-	expression tag
Gly 1267	-	expression tag
Ser 1268	-	expression tag
Gly 1269	-	expression tag
Gly 1270	-	expression tag
Ser 1271	-	expression tag
Ser 1272	-	expression tag
Ala 1273	-	expression tag
Trp 1274	-	expression tag
Ser 1275	-	expression tag
His 1276	-	expression tag
Pro 1277	-	expression tag
Gln 1278	-	expression tag
Phe 1279	-	expression tag
Glu 1280	-	expression tag
Lys 1281	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	19
	Total formula weight	677300.7
Branched	Number of molecules	12
	Total formula weight	5092.8
All*	Total formula weight	682393.5

*Water molecules are not included.