7E38

Crystal structure of deoxypodophyllotoxin synthase from Sinopodophyllum hexandrum in complex with yatein and succinate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Deoxypodophyllotoxin synthase	polymer	318	36140.1	2	UniProt (A0A0N9HQ36) Pfam (PF14226) Pfam (PF03171) In PDB	Sinopodophyllum hexandrum (Himalayan may apple)	2-oxoglutarate dependent dioxygenase
2	A, B	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
3	A, B	SUCCINIC ACID	non-polymer		118.1	2	Chemie (SIN)
4	A, B	(3~{S},4~{S})-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one	non-polymer		400.4	2	Chemie (YTC)
5	A, B	(3~{R},4~{R})-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one	non-polymer		400.4	2	Chemie (YTN)
6		water	water		18.0	451	Chemie (HOH)

Sequence modifications

A, B: 1 - 310 (UniProt: A0A0N9HQ36)

PDB	External Database	Details
Leu 311	-	expression tag
Glu 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72280.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1949.6
All*	Total formula weight	74229.8

*Water molecules are not included.