7E21

Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium/potassium-transporting ATPase subunit alpha-1	polymer	1023	113012.8	1	UniProt (P05023) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689)	Homo sapiens (human)	Na(+)/K(+) ATPase alpha-1 subunit,Sodium pump subunit alpha-1
2	B (B)	Sodium/potassium-transporting ATPase subunit beta-1	polymer	303	35108.3	1	UniProt (P05026) Pfam (PF00287)	Homo sapiens (human)	Sodium/potassium-dependent ATPase subunit beta-1
3	C (C)	Sodium/potassium-transporting ATPase subunit gamma	polymer	66	7292.3	1	UniProt (P54710) Pfam (PF02038)	Homo sapiens (human)	Na(+)/K(+) ATPase subunit gamma,FXYD domain-containing ion transport regulator 2,Sodium pump gamma chain
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E, F, G, H (A)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
6	I (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
7	J (A)	PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER	non-polymer		523.2	1	Chemie (AGS)
8	K, L, M, N, P... (A, B, C)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	6	Chemie (Y01)
9	O, Q (A, B)	1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		790.1	2	Chemie (PC1)
10	R (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
11	T (A)	water	water		18.0	5	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	155413.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	15
	Total formula weight	5361.4
All*	Total formula weight	161199.2

*Water molecules are not included.