7E1V
Cryo-EM structure of apo hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (E, Q) | Cytochrome c oxidase subunit 2 | polymer | 341 | 38077.5 | 2 | UniProt (A0R057) Pfam (PF00116) | Mycobacterium smegmatis MC2 51 | Cytochrome C oxidase subunit II ctaC |
| 2 | B, I (F, R) | Cytochrome c oxidase subunit 1 | polymer | 575 | 64163.0 | 2 | Mycolicibacterium smegmatis MC2 51 | ||
| 3 | C, J (G, S) | Cytochrome c oxidase subunit 3 | polymer | 203 | 22196.9 | 2 | UniProt (A0R049) Pfam (PF00510) | Mycobacterium smegmatis MC2 51 | Cytochrome c oxidase subunit 3 CtaE |
| 4 | D, K (H, T) | Cytochrome c oxidase polypeptide 4 | polymer | 139 | 15177.4 | 2 | UniProt (A0R056) Pfam (PF12270) | Mycobacterium smegmatis MC2 51 | Cytochrome aa3 subunit 4,Cytochrome c oxidase polypeptide IV |
| 5 | E, L (I, U) | Cytochrome c oxidase subunit CtaJ | polymer | 79 | 8365.5 | 2 | UniProt (A0R1B6) | Mycobacterium smegmatis MC2 51 | |
| 6 | F, M (J, V) | Uncharacterized protein MSMEG_4692/MSMEI_4575 | polymer | 157 | 15911.0 | 2 | UniProt (A0R1B5) Pfam (PF17174) | Mycobacterium smegmatis MC2 51 | Cytochrome c oxidase subunit CtaI |
| 7 | G, N (D, P) | Prokaryotic respiratory supercomplex associate factor 1 PRSAF1 | polymer | 100 | 11329.9 | 2 | Pfam (PF10939) UniProt (by SIFTS) (A0QVH4) | Mycolicibacterium smegmatis MC2 51 | |
| 8 | O, R (N, B) | Cytochrome bc1 complex cytochrome b subunit | polymer | 549 | 61077.1 | 2 | UniProt (P9WP37) Pfam (PF13631) | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrB,Ubiquinol--cytochrome c reductase cytochrome b subunit |
| 9 | P, S (M, A) | Cytochrome bc1 complex Rieske iron-sulfur subunit | polymer | 429 | 46976.5 | 2 | UniProt (P9WH23) Pfam (PF19297) Pfam (PF00355) | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrA,Rieske iron-sulfur protein,Ubiquinol--cytochrome c reductase iron-sulfur subunit |
| 10 | Q, T (O, C) | Cytochrome bc1 complex cytochrome c subunit | polymer | 280 | 29152.4 | 2 | UniProt (P9WP35) Pfam (PF00034) Pfam (PF13442) | Mycobacterium tuberculosis H37Rv | Cytochrome bc1 reductase complex subunit QcrC,Ubiquinol--cytochrome c reductase cytochrome c subunit |
| 11 | AA, FA, GA, HA, LA... (F, Q, R, E) | COPPER (II) ION | non-polymer | 63.5 | 8 | Chemie (CU) | |||
| 12 | AC, CB, EA, IA, JA... (C, M, D, R, B...) | CARDIOLIPIN | non-polymer | 1464.0 | 17 | Chemie (CDL) | |||
| 13 | JB, KA, TA, Y (B, R, N, F) | PALMITIC ACID | non-polymer | 256.4 | 4 | Chemie (PLM) | |||
| 14 | BA, CA, MA, NA (F, R) | HEME-A | non-polymer | 852.8 | 4 | Chemie (HEA) | |||
| 15 | DA, OA (G, S) | (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate | non-polymer | 718.0 | 2 | Chemie (9Y0) | |||
| 16 | KB, LB, QA, RA (B, N) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 17 | AB, FB, GB, QB, RB... (N, O, B, C) | MENAQUINONE-9 | non-polymer | 785.2 | 10 | Chemie (MQ9) | |||
| 18 | BB, SB (M, A) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 19 | DB, EB, TB, UB (M, A) | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate | non-polymer | 853.1 | 4 | Chemie (9YF) | |||
| 20 | HB, IB, VB, WB (O, C) | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) |
Sequence modifications
O, C: 2 - 280 (UniProt: P9WP35)
| PDB | External Database | Details |
|---|---|---|
| Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 624854.1 | |
| Non-Polymers* | Number of molecules | 59 |
| Total formula weight | 47826.5 | |
| All* | Total formula weight | 672680.6 |
