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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7DW9

Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		Vasopressin V2 receptorpolymer64571063.71UniProt (P30518)
Pfam (PF00001)		Homo sapiens (Human)V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor
2B
(A)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer36141879.51Pfam (PF00503)
UniProt (by SIFTS) (P63096)
UniProt (by SIFTS) (P63092)		Homo sapiens
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37140227.01UniProt (P54311)
Pfam (PF00400)		Rattus norvegicus (Rat)Transducin beta chain 1
4D
(Y)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)		Bos taurus (Bovine)G gamma-I
5E
(N)		Nanobody35polymer14015343.01synthetic construct
6F
(S)		scFv16polymer24726277.31synthetic construct
7G
(C)		CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2polymer101086.21Pfam (PF00220)
UniProt (by SIFTS) (P01185)		Homo sapiens
8H, I, J
(R)		CHOLESTEROLnon-polymer386.73Chemie (CLR)
Sequence modifications
R: 1 - 371 (UniProt: P30518)
PDBExternal DatabaseDetails
His -115-expression tag
His -114-expression tag
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His -106-expression tag
Ala -105-expression tag
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Leu -103-expression tag
Glu -102-expression tag
Asp -101-expression tag
Asn -100-expression tag
Trp -99-expression tag
Glu -98-expression tag
Thr -97-expression tag
Leu -96-expression tag
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Leu -92-expression tag
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Val -90-expression tag
Ile -89-expression tag
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Gln -81-expression tag
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Ala -77-expression tag
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Arg -72-expression tag
Ala -71-expression tag
Ala -70-expression tag
Ala -69-expression tag
Leu -68-expression tag
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Ala -66-expression tag
Gln -65-expression tag
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Ala -63-expression tag
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Leu -38-expression tag
Val -37-expression tag
Gly -36-expression tag
Gln -35-expression tag
Ile -34-expression tag
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Ala -31-expression tag
Leu -30-expression tag
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Leu -28-expression tag
Ala -27-expression tag
Asn -26-expression tag
Glu -25-expression tag
Gly -24-expression tag
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Val -22-expression tag
Lys -21-expression tag
Glu -20-expression tag
Ala -19-expression tag
Gln -18-expression tag
Ala -17-expression tag
Ala -16-expression tag
Ala -15-expression tag
Glu -14-expression tag
Gln -13-expression tag
Leu -12-expression tag
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Arg -8-expression tag
Asn -7-expression tag
Ala -6-expression tag
Tyr -5-expression tag
Ile -4-expression tag
Gln -3-expression tag
Lys -2-expression tag
Tyr -1-expression tag
Leu 0-expression tag
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His 429-expression tag
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Ile 431-expression tag
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Tyr 434-expression tag
Glu 435-expression tag
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Ile 445-expression tag
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Lys 450-expression tag
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Tyr 453-expression tag
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Ile 527-expression tag
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Ser 529-expression tag
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
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Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
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Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight203737.9
Non-Polymers*Number of molecules3
Total formula weight1160.0
All*Total formula weight204897.8
*Water molecules are not included.

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PDB entries from 2024-10-30

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