7DQQ
Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase Y91F/C120S variant in complex with O6-methyldeoxyguanosine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methylated-DNA--protein-cysteine methyltransferase | polymer | 156 | 17944.9 | 1 | UniProt (Q973C7) Pfam (PF02870) Pfam (PF01035) | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase |
| 2 | B (A) | (2~{R},3~{S},5~{R})-5-(2-azanyl-6-methoxy-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol | non-polymer | 281.3 | 1 | Chemie (J03) PubChem (73317) PubChem (264742) PubChem (3246365) PubChem (92223722) PubChem (154710689) PubChem (86295173) PubChem (92223721) PubChem (92223723) PubChem (92441101) PubChem (121235272) PubChem (142619547) PubChem (171699423) | |||
| 3 | C (A) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 1 - 156 (UniProt: Q973C7)
| PDB | External Database | Details |
|---|---|---|
| Phe 91 | Tyr 91 | engineered mutation |
| Ser 120 | Cys 120 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17944.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 281.3 | |
| All* | Total formula weight | 18226.2 |
