7DOZ
HIV-1 Protease D30N mutant in complex with Nelfinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protease | polymer | 203 | 21932.8 | 1 | UniProt (Q72874) Pfam (PF00077) UniProt (by SIFTS) (P04585) | Human immunodeficiency virus 1 | Retropepsin |
| 2 | B, C (A) | 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE | non-polymer | 567.8 | 2 | Chemie (1UN) | |||
| 3 | D (A) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q72874)
A: 1001 - 1099 (UniProt: Q72874)
| PDB | External Database | Details |
|---|---|---|
| Asn 30 | Asp 30 | engineered mutation |
| Met 95 | Cys 95 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 996 | - | linker |
| Gly 997 | - | linker |
| Ser 998 | - | linker |
| Ser 999 | - | linker |
| Gly 1000 | - | linker |
| Asn 1030 | Asp 30 | engineered mutation |
| Ala 1095 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21932.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1135.6 | |
| All* | Total formula weight | 23068.4 |
