7DOI
Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase | polymer | 943 | 107965.3 | 1 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 12 |
| 2 | B, F (B, G) | Non-structural protein 8 | polymer | 199 | 22034.2 | 2 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | |
| 3 | C (C) | Non-structural protein 7 | polymer | 84 | 9380.0 | 1 | UniProt (P0DTD1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | |
| 4 | D (P) | RNA (5'-R(P*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3') | polymer | 12 | 3822.3 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | E (T) | RNA (5'-R(P*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*U)-3') | polymer | 15 | 4658.8 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 6 | G, H (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I, N (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 2 | Chemie (POP) | |||
| 8 | J, K, L, M (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 9 | O (P) | [(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate | non-polymer | 333.2 | 1 | Chemie (HCU) | |||
| 10 | P, Q (A, P) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 1 - 932 (UniProt: P0DTD1)
B, G: 1 - 198 (UniProt: P0DTD1)
C: 1 - 83 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Gly 933 | - | expression tag |
| Gly 934 | - | expression tag |
| Ser 935 | - | expression tag |
| Glu 936 | - | expression tag |
| Asn 937 | - | expression tag |
| Leu 938 | - | expression tag |
| Tyr 939 | - | expression tag |
| Phe 940 | - | expression tag |
| Gln 941 | - | expression tag |
| Gly 942 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169894.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 913.2 | |
| All* | Total formula weight | 170808.0 |
