7DIA
Falcilysin in complex with mefloquine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Falcilysin | polymer | 1158 | 135039.4 | 1 | UniProt (Q76NL8) Pfam (PF00675) Pfam (PF05193) Pfam (PF08367) Pfam (PF22516) In PDB | Plasmodium falciparum 3D7 | |
| 2 | A | (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol | non-polymer | 378.3 | 1 | Chemie (H8O) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | A | Mefloquine | non-polymer | 378.3 | 1 | Chemie (YMZ) | |||
| 6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 7 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | water | water | 18.0 | 1312 | Chemie (HOH) |
Sequence modifications
A: 59 - 1193 (UniProt: Q76NL8)
| PDB | External Database | Details |
|---|---|---|
| Met 36 | - | initiating methionine |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| Ser 43 | - | expression tag |
| Ser 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Val 46 | - | expression tag |
| Asp 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Gly 49 | - | expression tag |
| Thr 50 | - | expression tag |
| Glu 51 | - | expression tag |
| Asn 52 | - | expression tag |
| Leu 53 | - | expression tag |
| Tyr 54 | - | expression tag |
| Phe 55 | - | expression tag |
| Gln 56 | - | expression tag |
| Ser 57 | - | expression tag |
| Met 58 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 135039.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1339.5 | |
| All* | Total formula weight | 136378.9 |
