7DHL

Crystal structure of FGFR3 in complex with pyrimidine derivative

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 3	polymer	313	35664.7	1	UniProt (P22607) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-3
2	A	5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine	non-polymer		546.7	1	Chemie (H6X)
3		water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 472 - 759 (UniProt: P22607)

PDB	External Database	Details
Gly 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
Met 450	-	expression tag
Leu 451	-	expression tag
Ala 452	-	expression tag
Gly 453	-	expression tag
Val 454	-	expression tag
Ser 455	-	expression tag
Glu 456	-	expression tag
Tyr 457	-	expression tag
Glu 458	-	expression tag
Leu 459	-	expression tag
Pro 460	-	expression tag
Glu 461	-	expression tag
Asp 462	-	expression tag
Pro 463	-	expression tag
Lys 464	-	expression tag
Trp 465	-	expression tag
Glu 466	-	expression tag
Phe 467	-	expression tag
Pro 468	-	expression tag
Arg 469	-	expression tag
Asp 470	-	expression tag
Lys 471	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35664.7
Non-Polymers*	Number of molecules	1
	Total formula weight	546.7
All*	Total formula weight	36211.4

*Water molecules are not included.