7DEE

Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CASP8 and FADD-like apoptosis regulator	polymer	185	21588.2	1	UniProt (O15519) Pfam (PF01335) In PDB	Homo sapiens (Human)	Caspase homolog,CASH,Caspase-eight-related protein,Casper,Caspase-like apoptosis regulatory protein,CLARP,Cellular FLICE-like inhibitory protein,c-FLIP,FADD-like antiapoptotic molecule 1,FLAME-1,Inhibitor of FLICE,I-FLICE,MACH-related inducer of toxicity,MRIT,Usurpin
2	B	C8-H1a	polymer	8	1030.1	1	UniProt (by SIFTS) (Q14790) In PDB	Homo sapiens

Sequence modifications

A: 6 - 177 (UniProt: O15519)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Arg 3	-	expression tag
Ser 4	-	expression tag
Asp 5	-	expression tag
Gly 118	Phe 114	engineered mutation
Leu 178	-	expression tag
Glu 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22618.3
All*	Total formula weight	22618.3

*Water molecules are not included.