7DDH

Crystal structures of Na+,K+-ATPase in complex with digoxin

Replaces:  6KPW

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, C)	Sodium/potassium-transporting ATPase subunit alpha-1	polymer	1016	112403.9	2	UniProt (P05024) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689)	Sus scrofa (Pig)	Na(+)/K(+) ATPase alpha-1 subunit,Sodium pump subunit alpha-1
2	B, E (B, D)	Sodium/potassium-transporting ATPase subunit beta-1	polymer	303	35204.4	2	UniProt (P05027) Pfam (PF00287)	Sus scrofa (Pig)	Sodium/potassium-dependent ATPase subunit beta-1
3	C, F (G, E)	FXYD domain-containing ion transport regulator	polymer	65	7094.1	2	UniProt (Q58K79)	Sus scrofa (Pig)	Na+/K+ ATPase gamma subunit transcript variant a
4	G, H, I, J (F, H, I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	BA, K, M, Z (C, A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
6	AA, L (C, A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA) PubChem (923)
7	IA, JA, N, V, X... (D, E, A, B, G...)	CHOLESTEROL	non-polymer		386.7	6	Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573)
8	CA, DA, EA, FA, O... (C, A, B)	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	10	Chemie (PCW)
9	GA, T (C, A)	DIGOXIN	non-polymer		780.9	2	Chemie (DGX) PubChem (16394506) PubChem (16403371) PubChem (16757666) PubChem (3062) PubChem (16757557) PubChem (22833572) PubChem (24031098) PubChem (24837624) PubChem (45073400) PubChem (45358124) PubChem (44145769) PubChem (44659596) PubChem (45933566) PubChem (44663291) PubChem (52931493) PubChem (53477737) PubChem (58559695) PubChem (58616976) PubChem (2724385) PubChem (57358314) PubChem (58695607) PubChem (58616975) PubChem (59173065) PubChem (60055842) PubChem (60134752) PubChem (66683216) PubChem (70920464) PubChem (70920537) PubChem (71316113) PubChem (5702042) PubChem (176519989) PubChem (30322) PubChem (194123) PubChem (70882148) PubChem (70886579) PubChem (70920463) PubChem (90346909) PubChem (73265414) PubChem (73707466) PubChem (73759829) PubChem (86579129) PubChem (12940973) PubChem (12940984) PubChem (117072395) PubChem (117627601) PubChem (117686431) PubChem (117777085) PubChem (6604360) PubChem (124112976) PubChem (124746530) PubChem (124746526) PubChem (124898317) PubChem (124898843) PubChem (124898845) PubChem (124901334) PubChem (124900891) PubChem (124902043) PubChem (124902038) PubChem (126657056) PubChem (129121359) PubChem (129606042) PubChem (130476760) PubChem (131801316) PubChem (133688115) PubChem (134370198) PubChem (134694175) PubChem (135056324) PubChem (135391146) PubChem (124746527) PubChem (124746528) PubChem (124746529) PubChem (12940990) PubChem (12940955) PubChem (12940972) PubChem (12940977) PubChem (124898321) PubChem (124898324) PubChem (124898326) PubChem (124898844) PubChem (124898847) PubChem (124900892) PubChem (124900895) PubChem (124900897) PubChem (124901335) PubChem (124901336) PubChem (124901337) PubChem (124902041) PubChem (124902044) PubChem (129010261) PubChem (129121360) PubChem (140501613) PubChem (140635266) PubChem (133550128) PubChem (155765066) PubChem (159451917) PubChem (162898443) PubChem (162898448) PubChem (140635282) PubChem (140889045) PubChem (145738015) PubChem (154496482) PubChem (170386604) PubChem (172011968) PubChem (172871753) PubChem (159451916) PubChem (162411201) PubChem (175619468) PubChem (162898444) PubChem (162898445) PubChem (162898446) PubChem (162898447) PubChem (169854558) PubChem (175674824)
10	HA, U (D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
11	KA, LA (A, C)	water	water		18.0	10	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	309404.9
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	26
	Total formula weight	12338.6
All*	Total formula weight	323441.2

*Water molecules are not included.