7DD1

Crystal structure of SRPK1 in complex with a peptide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	SRSF protein kinase 1,SRSF protein kinase 1	polymer	398	45322.0	1	UniProt (Q96SB4-2) Pfam (PF00069) UniProt (by SIFTS) (Q96SB4)	Homo sapiens (Human)
2	B (B)	ARG-GLU-ARG-ALA-ARG-THR-ARG	polymer	7	948.1	1		Peptide display vector fth1
3	C, D (A, B)	water	water		18.0	260	Chemie (HOH)

Sequence modifications

A: 58 - 472 (UniProt: Q96SB4-2)

PDB	External Database	Details
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag
His 45	-	expression tag
His 46	-	expression tag
Ser 47	-	expression tag
Ser 48	-	expression tag
Gly 49	-	expression tag
Leu 50	-	expression tag
Val 51	-	expression tag
Pro 52	-	expression tag
Arg 53	-	expression tag
Gly 54	-	expression tag
Ser 55	-	expression tag
His 56	-	expression tag
Met 57	-	expression tag

A: 474 - 655 (UniProt: Q96SB4-2)

PDB	External Database	Details
Ala 473	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46270.1
All*	Total formula weight	46270.1

*Water molecules are not included.