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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7D7M

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtypepolymer33336953.51UniProt (P35408)
Pfam (PF00001)		Homo sapiens (Human)PGE2 receptor EP4 subtype,Prostanoid EP4 receptor,PGE2 receptor EP4 subtype,Prostanoid EP4 receptor
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537728.21UniProt (P62873)
Pfam (PF25391)		Homo sapiens (Human)Transducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (Human)G gamma-I
4D
(D)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24929014.81UniProt (P63092)
Pfam (PF00503)		Homo sapiens (Human)Adenylate cyclase-stimulating G alpha protein,Adenylate cyclase-stimulating G alpha protein,Adenylate cyclase-stimulating G alpha protein
5E
(E)		nanobody Nb35polymer13414680.31Lama glama
6F
(A)		(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acidnon-polymer352.51Chemie (P2E)
PubChem (16219826)
PubChem (71195864)
PubChem (176729059)
PubChem (177546178)
PubChem (35021823)
PubChem (35021833)
PubChem (26436117)
PubChem (40575690)
PubChem (35027359)
PubChem (40575698)
PubChem (44444717)
PubChem (49822699)
PubChem (91886115)
PubChem (5280360)
PubChem (97041839)
PubChem (53477468)
PubChem (54466054)
PubChem (54466055)
PubChem (54466056)
PubChem (54466057)
PubChem (57357999)
PubChem (12314587)
PubChem (156359195)
PubChem (171042408)
PubChem (59294054)
PubChem (59881728)
PubChem (59926133)
PubChem (59941509)
PubChem (59968515)
PubChem (67937739)
PubChem (70419675)
PubChem (71082424)
PubChem (71401211)
PubChem (73357245)
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PubChem (97041838)
PubChem (158)
PubChem (122176715)
PubChem (9691)
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PubChem (122348)
PubChem (124350425)
PubChem (124406582)
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PubChem (124524501)
PubChem (3246816)
PubChem (3246832)
PubChem (5283061)
PubChem (5283086)
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PubChem (5283213)
PubChem (5353587)
PubChem (6445999)
PubChem (6450019)
PubChem (9874974)
PubChem (9950404)
PubChem (10247450)
PubChem (11221902)
PubChem (11581143)
PubChem (12041746)
PubChem (12314577)
PubChem (12314580)
PubChem (12314582)
PubChem (12314584)
PubChem (12314585)
PubChem (12314588)
PubChem (12314590)
PubChem (12314594)
PubChem (131954610)
PubChem (139503973)
PubChem (149202340)
PubChem (154166399)
PubChem (155114512)
PubChem (156358885)
PubChem (156359009)
PubChem (156681952)
PubChem (156681960)
PubChem (162705518)
PubChem (163091488)
PubChem (163091489)
PubChem (166639831)
PubChem (166639839)
PubChem (166639992)
PubChem (169502219)
PubChem (171157690)
PubChem (172878425)
PubChem (173974797)
PubChem (175594575)
Sequence modifications
A: 4 - 217 (UniProt: P35408)
PDBExternal DatabaseDetails
Gly 0-expression tag
Pro 1-expression tag
Thr 2-expression tag
Ser 3-expression tag
Gln 7Asn 7engineered mutation
Gln 177Asn 177engineered mutation
A: 260 - 366 (UniProt: P35408)
PDBExternal DatabaseDetails
Leu 367-expression tag
Glu 368-expression tag
Leu 369-expression tag
Glu 370-expression tag
Val 371-expression tag
Leu 372-expression tag
Phe 373-expression tag
Gln 374-expression tag
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
D: 5 - 64 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 49Gly 49engineered mutation
Asn 50Glu 50engineered mutation
Tyr 63Leu 63engineered mutation
D: 204 - 254 (UniProt: P63092)
PDBExternal DatabaseDetails
Gly 196-linker
Gly 197-linker
Ser 198-linker
Gly 199-linker
Gly 200-linker
Ser 201-linker
Gly 202-linker
Gly 203-linker
Asp 249Ala 249engineered mutation
Asp 252Ser 252engineered mutation
D: 265 - 394 (UniProt: P63092)
PDBExternal DatabaseDetails
Ala 372Ile 372engineered mutation
Ile 375Val 375engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight126237.8
Non-Polymers*Number of molecules1
Total formula weight352.5
All*Total formula weight126590.3
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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