7D77
Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 226 | 25286.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P09471) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38245.8 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (R) | Adhesion G protein-coupled receptor G3; GPR97 | polymer | 561 | 62767.1 | 1 | Pfam (PF01825) Pfam (PF00002) UniProt (by SIFTS) (Q86Y34) | Homo sapiens | |
| 5 | E (S) | scFv16 | polymer | 250 | 26610.6 | 1 | synthetic construct | ||
| 6 | F, H, I (A, R) | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) | |||
| 7 | G (R) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 8 | J (R) | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione | non-polymer | 362.5 | 1 | Chemie (HCY) | |||
| 9 | K, L (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 10 | M (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 1 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 160771.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2391.8 | |
| All* | Total formula weight | 163163.3 |
