7D5U
BACE2 xaperone complex with N-{3-[(9S)-7-amino-2,2-difluoro-9-(prop-1-yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluorophenyl}-5-cyanopyridine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-secretase 2 | polymer | 386 | 42105.4 | 1 | UniProt (Q9Y5Z0) Pfam (PF00026) | Homo sapiens (Human) | Aspartic-like protease 56 kDa,Aspartyl protease 1,Asp 1,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Down region aspartic protease,DRAP,Memapsin-1,Membrane-associated aspartic protease 1,Theta-secretase |
| 2 | B (D) | xaperone | polymer | 114 | 12106.4 | 1 | Homo sapiens | ||
| 3 | C (A) | N-[3-[(9S)-7-azanyl-2,2-bis(fluoranyl)-9-prop-1-ynyl-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluoranyl-phenyl]-5-cyano-pyridine-2-carboxamide | non-polymer | 453.4 | 1 | Chemie (GX6) | |||
| 4 | D, E (A, D) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54211.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 453.4 | |
| All* | Total formula weight | 54665.3 |
