7D5B
BACE2 xaperone complex with N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-secretase 2 | polymer | 386 | 42105.4 | 1 | UniProt (Q9Y5Z0) Pfam (PF00026) In PDB | Homo sapiens | Aspartic-like protease 56 kDa,Aspartyl protease 1,Asp 1,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Down region aspartic protease,DRAP,Memapsin-1,Membrane-associated aspartic protease 1,Theta-secretase |
| 2 | D | XAPERONE | polymer | 112 | 11897.2 | 1 | Homo sapiens | ||
| 3 | A | N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide | non-polymer | 409.4 | 1 | Chemie (66F) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | A, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | A, D | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 535 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54002.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 677.0 | |
| All* | Total formula weight | 54679.7 |
