7D4B
Crystal structure of 4-1BB in complex with a VHH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tumor necrosis factor receptor superfamily member 9 | polymer | 140 | 15046.0 | 1 | UniProt (Q07011) Pfam (PF00020) | Homo sapiens (Human) | 4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA |
| 2 | B (B) | anti-4-1BB VHH | polymer | 127 | 13852.4 | 1 | Lama glama | ||
| 3 | C (C) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1219.1 | 1 | In PDB GlyTouCan (G32156ZV) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | E, F, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | G, H, L (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | J, K (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | M, N (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 25 - 162 (UniProt: Q07011)
| PDB | External Database | Details |
|---|---|---|
| Leu 163 | - | expression tag |
| Gly 164 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28898.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1789.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 518.7 | |
| All* | Total formula weight | 31206.7 |
