7D3V
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DNA dC->dU-editing enzyme APOBEC-3A | polymer | 199 | 23049.9 | 2 | UniProt (P31941) Pfam (PF05240) In PDB | Homo sapiens (Human) | A3A,Phorbolin-1 |
| 2 | C, D | DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3') | polymer | 10 | 3009.0 | 2 | synthetic construct | ||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 199 (UniProt: P31941)
| PDB | External Database | Details |
|---|---|---|
| Asn 63 | Leu 63 | engineered mutation |
| Ser 64 | Cys 64 | engineered mutation |
| Gln 72 | Glu 72 | engineered mutation |
| Gln 171 | Cys 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 52117.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 52248.6 |
