7D3E
Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Dual oxidase 1 | polymer | 1551 | 177483.8 | 2 | UniProt (Q9NRD9) Pfam (PF03098) Pfam (PF00036) Pfam (PF13499) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (Human) | Large NOX 1,Long NOX 1,NADPH thyroid oxidase 1,Thyroid oxidase 1 |
| 2 | B, D (B, D) | Isoform 2 of Dual oxidase maturation factor 1 | polymer | 483 | 53579.2 | 2 | UniProt (Q1HG43) Pfam (PF10204) | Homo sapiens (Human) | Dual oxidase activator 1,Numb-interacting protein |
| 3 | E, F (E, F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 2 | In PDB GlyTouCan (G40702WU) | |||
| 4 | G, H, R, S (A, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 5 | I, T (A, C) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 6 | J, U (A, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 7 | AA, BA, K, L, M... (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 8 | N, O, Y, Z (A, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 9 | CA, DA (A, C) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 1551 (UniProt: Q9NRD9)
| PDB | External Database | Details |
|---|---|---|
| Phe 1178 | Leu 1178 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 462126.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3443.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 7831.9 | |
| All* | Total formula weight | 473401.0 |
