7D3C
The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | 3C-like proteinase | polymer | 306 | 33355.2 | 2 | UniProt (A0A0D3MU45) Pfam (PF05409) UniProt (by SIFTS) (K9N7C7) In PDB | Middle East respiratory syndrome-related coronavirus (MERS-CoV) | nsp5, Growth factor-like peptide,Leader protein,Non-structural protein 10,Non-structural protein 2,Non-structural protein 3,Non-structural protein 4,Non-structural protein 6,Non-structural protein 7,Non-structural protein 8,Non-structural protein 9,Papain-like proteinase,p65 homolog |
| 2 | C, E | N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | polymer | 6 | 680.8 | 2 | BIRD (PRD_002214) | synthetic construct | |
| 3 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 306 (UniProt: A0A0D3MU45)
| PDB | External Database | Details |
|---|---|---|
| Asp 34 | Asn 3191 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68071.9 | |
| All* | Total formula weight | 68071.9 |
