7D20
Cryo-EM structure of SET8-CENP-A-nucleosome complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E | Histone H3-like centromeric protein A | polymer | 143 | 16305.9 | 2 | UniProt (P49450) Pfam (PF00125) In PDB | Homo sapiens (Human) | Centromere autoantigen A,Centromere protein A,CENP-A |
| 2 | B, F | Histone H4 | polymer | 106 | 11676.7 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (Human) | |
| 3 | C, G | Histone H2A type 1-B/E | polymer | 133 | 14447.8 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (Human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D, H | Histone H2B type 1-J | polymer | 129 | 14217.5 | 2 | UniProt (P06899) Pfam (PF00125) In PDB | Homo sapiens (Human) | Histone H2B.1,Histone H2B.r,H2B/r |
| 5 | I | DNA (145-MER) | polymer | 145 | 44520.4 | 1 | synthetic construct | ||
| 6 | J | DNA (145-MER) | polymer | 145 | 44991.7 | 1 | synthetic construct | ||
| 7 | K | Isoform 2 of N-lysine methyltransferase KMT5A | polymer | 352 | 39295.8 | 1 | UniProt (Q9NQR1) Pfam (PF00856) In PDB | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
Sequence modifications
A, E: 1 - 140 (UniProt: P49450)
B, F: 1 - 102 (UniProt: P62805)
C, G: 1 - 129 (UniProt: P04908)
D, H: 1 - 125 (UniProt: P06899)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 242103.7 | |
| All* | Total formula weight | 242103.7 |
